STUDIES ON IMMUNITY OF REVACCINATION

Increasing herd immunity with influenza revaccination.

Seasonal influenza is a significant public health concern globally. While influenza vaccines are the single most effective intervention to reduce influenza morbidity and mortality, there is considerable debate surrounding the merits and consequences of repeated seasonal vaccination. Here, we describe a two-season influenza epidemic contact network model and use it to demonstrate that increasing...

Studies on Pneumococcus Immunity

1. Active immunity against many lethal doses of Pneumococcus Types I, II, and III may be produced in mice by two or three subcutaneous injections of the homologous type of pneumococcus saline vaccine. 2. Mice may be actively immunized with the protein fraction obtained by treating pneumococci with anhydrous sodium sulfate or by solution of pneumococci in bile salts and precipitation with alcoho...

Studies on Antiblastic Immunity

Antipneumococcus serum under certain conditions apparently inhibits or retards the metabolic activities of the homologous pneumococcus. Antipneumococcus serum exhausted of its agglutinin content possesses no inhibitory properties. The degree of inhibitory action of antipneumococcus serum parallels its agglutinating power. No evidence has been found to indicate that the inhibition of the metabol...

Studies on Immunity in Cancers

Studies on Immunity in Anthrax

Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without des...